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Biomarkers

BRCA mutations confer high risk of CNS metastases

BRCA mutations confer high risk of CNS metastases

Patients with newly recurrent breast cancer who carry a germline BRCA1 or BRCA2 mutation are about twice as likely as noncarriers to have central nervous system involvement, finds a single-center retrospective cohort study. And carrying a BRCA2 mutation independently predicts such involvement and death from the disease.

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